[Comment] Personalised prevention therapy in type 1 diabetes

00:00 - 11 Nov 2025

Type 1 diabetes is an autoimmune disease in which the insulin-producing β cells in the pancreatic islets of Langerhans are destroyed by islet-autoreactive T cells in individuals with genetic predisposition to this disease.1,2 Despite considerable development in technologies improving glycaemic control, insulin replacement treats the symptoms of type 1 diabetes but not its cause, and diabetic complications arise that increase mortality. Therapy to prevent or intervene in the disease process and preserve β-cell function is needed, but immunosuppressive therapies have not led to durable patient benefit so far, with clinical efficacy being restricted to subgroups of patients.