DNA Mutations Discovered In the Children of Chernobyl Workers

00:00 - 15 Feb 2026

Researchers performed genome sequencing scans on 130 people whose fathers were Chernobyl cleanup workers. Comparing the scans to control groups, they found evidence for the first time for "a transgenerational effect" from the father's prolonged exposure to low-dose ionizing radiation. ScienceAlert reports: Rather than picking out new DNA mutations in the next generation, they looked for what are known as clustered de novo mutations (cDNMs): two or more mutations in close proximity, found in the children but not the parents. These would be mutations resulting from breaks in the parental DNA caused by radiation exposure. "We found a significant increase in the cDNM count in offspring of irradiated parents, and a potential association between the dose estimations and the number of cDNMs in the respective offspring," write the researchers in their published paper... This fits with the idea that radiation creates molecules known as reactive oxygen species, which are able to break DNA strands — breaks which can leave behind the clusters described in this study, if repaired imperfectly. The good news is that the risk to health should be relatively small: children of exposed parents weren't found to have any higher risk of disease. This is partly because a lot of the cDNMs likely fall in 'non-coding' DNA, rather than in genes that directly encode proteins.

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