Nature, Published online: 14 January 2026; doi:10.1038/d41586-026-00069-y

Symmetrical arrangements of botanical motifs indicate a grasp of spatial division long before the advent of formal written numbers.

Nature, Published online: 14 January 2026; doi:10.1038/d41586-026-00147-1

Six experts at the forefront of AI development give their opinions on what is next for the field.

Nature, Published online: 14 January 2026; doi:10.1038/d41586-026-00161-3

A rare sample from a woolly rhinoceroses reveals how the population changed in the lead-up to the species’ extinction.

Nature, Published online: 14 January 2026; doi:10.1038/d41586-026-00145-3

More than half of Gen Z now have a side gig. Are researchers among those seeking a second income?

Nature, Published online: 14 January 2026; doi:10.1038/d41586-026-00162-2

Artificial intelligence use can boost outputs, at the cost of research breadth — plus, solving the mystery of the Universe’s ‘little red dots’.

Nature, Published online: 14 January 2026; doi:10.1038/s41586-026-10104-7

Retraction Note: Antibodies against endogenous retroviruses promote lung cancer immunotherapy

Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09949-1

Colourful patterns in two-dimensional lead halide perovskites are created by letting them self-etch into tiny squares that can template epitaxial growth.

Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09960-6

A survey of the reconstructed gene set of the last eukaryotic common ancestor shows a consistent link between Asgard archaea and the origin of numerous, functionally diverse eukaryotic genes, demonstrating the dominant Asgard contribution to eukaryogenesis.

Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09913-z

Molecular mimicry between a gut commensal and a tumour antigen forms part of an important mechanistic framework that can boost the efficacy of immune checkpoint blockade therapy and restrain tumour growth.

Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09904-0

Fabrication of fully stretchable organic light-emitting diodes incorporating an intrinsically stretchable exciplex-assisted phosphorescent layer along with MXene-contact stretchable electrodes is described, demonstrating high efficiency and mechanical compliance for applications in next-generation wearable and deformable displays.

A new discovery may explain why so many people abandon cholesterol-lowering statins because of muscle pain and weakness. Researchers found that certain statins can latch onto a key muscle protein and trigger a tiny but harmful calcium leak inside muscle cells. That leak may weaken muscles directly or activate processes that slowly break them down, offering a long-sought explanation for statin-related aches.

Scientists have identified a newly recognized threat lurking beneath the ocean’s surface: sudden episodes of underwater darkness that can last days or even months. Caused by storms, sediment runoff, algae blooms, and murky water, these “marine darkwaves” dramatically reduce light reaching the seafloor, putting kelp forests, seagrass, and other light-dependent life at risk.

Scientists are taking a closer look at monk fruit and discovering it’s more than just a sugar substitute. New research shows its peel and pulp contain a rich mix of antioxidants and bioactive compounds that may support health. Different varieties offer different chemical profiles, hinting at unique benefits. The work could shape how monk fruit is used in future foods and supplements.

A massive international brain study has revealed that memory decline with age isn’t driven by a single brain region or gene, but by widespread structural changes across the brain that build up over time. Analyzing thousands of MRI scans and memory tests from healthy adults, researchers found that memory loss accelerates as brain tissue shrinkage increases, especially later in life. While the hippocampus plays a key role, many other brain regions also contribute, forming a broad vulnerability rather than isolated damage.

Earth’s oceans reached their highest heat levels on record in 2025, absorbing vast amounts of excess energy from the atmosphere. This steady buildup has accelerated since the 1990s and is now driving stronger storms, heavier rainfall, and rising sea levels. While surface temperatures fluctuate year to year, the ocean’s long-term warming trend shows no sign of slowing.

A new study reveals that alpha brain waves help the brain decide what belongs to your body. Faster rhythms allow the brain to match sight and touch more precisely, strengthening the feeling that a body part is truly yours. Slower rhythms blur that timing, making it harder to separate self from surroundings. The findings could improve prosthetic design and immersive virtual experiences.

Some people get drunk without drinking because their gut bacteria produce alcohol from food. Researchers have now identified the microbes and biological pathways behind this rare condition, auto-brewery syndrome. Tests showed patients’ gut samples produced far more alcohol than those of healthy people. In one case, a fecal transplant led to long-lasting symptom relief.

Despite longstanding guidelines, many dementia patients are still prescribed brain-altering medications that can raise the risk of falls and confusion. A new study shows that while prescribing has decreased overall, people with cognitive impairment remain more likely to receive these drugs. In many cases, there was no documented medical justification. The results suggest that medication safety remains a serious concern in dementia care.

A damaging cotton virus thought to be a recent invader has actually been hiding in U.S. fields for nearly two decades. New research shows cotton leafroll dwarf virus was present as early as 2006, quietly spreading across major cotton-growing states long before it was officially identified. By reanalyzing old genetic data with modern tools, scientists uncovered a hidden history of the virus’s spread—including its first confirmed appearance in California and even traces in animal feed.

A generative AI system can now analyze blood cells with greater accuracy and confidence than human experts, detecting subtle signs of diseases like leukemia. It not only spots rare abnormalities but also recognizes its own uncertainty, making it a powerful support tool for clinicians.

SETI@home, the pioneering distributed-computing project launched in 1999 that enlisted millions of volunteers to analyze radio signals from space, produced some 12 billion detections -- brief bursts of energy that stood out from background noise -- as it combed through observations recorded at the now-defunct Arecibo Observatory in Puerto Rico.

The post Millions Joined SETI@home Project, Now Astronomers Zero In on 100 Promising Signals appeared first on Sci.News: Breaking Science News.

At Leang Bulu Bettue, a rock-shelter in the Maros-Pangkep karst region on the Indonesian island of Sulawesi, paleoanthropologists have uncovered one of the most complete records of early human occupation ever found in Wallacea.

The post Enigmatic Hominins May Have Overlapped with Homo sapiens on Sulawesi appeared first on Sci.News: Breaking Science News.

A fish species called the armored rockhead poacher (Bothragonus swanii) carries a secret that has confounded marine biologists for decades: a deep, bowl-shaped hole in the middle of its skull.

The post Scientist Finds Built-In Drum in Head of Weird-Looking Fish appeared first on Sci.News: Breaking Science News.

Astronomers using NASA’s James Webb Space Telescope have captured the most detailed infrared view yet into the center of the Circinus Galaxy, one of the closest known active galaxies to the Milky Way.

The post Webb Peers into Heart of Circinus Galaxy appeared first on Sci.News: Breaking Science News.

In new experiments aboard the International Space Station (ISS), microbiologists from the University of Wisconsin-Madison and Rhodium Scientific Inc. have discovered that the near-weightless environment of space can significantly reshape how bacteriophages -- viruses that infect bacteria -- interact with their hosts.

The post Microgravity on International Space Station Alters Coevolution of Bacteriophages and Their Hosts appeared first on Sci.News: Breaking Science News.

Using the high resolution images from the NIRCam (Near-InfraRed Camera) instrument onboard the NASA/ESA James Webb Space Telescope, astronomers have spotted one of the earliest barred spiral galaxies known, shaping our view of cosmic evolution.

The post Barred Spiral Galaxy Spotted Just Two Billion Years after Big Bang appeared first on Sci.News: Breaking Science News.

A team of paleontologists from Mexico and the United States has identified a new species of bird-like dinosaur with an unusually thick and domed skull, suggesting it may have used head-butting during combat with members of its own species.

The post Thick-Skulled Troodontid Dinosaur Unearthed in Mexico appeared first on Sci.News: Breaking Science News.

Physicists from the Center of Applied Space Technology and Microgravity at the University of Bremen and the Transylvanian University of Brașov have unveiled a new theoretical framework that could rewrite how we understand the accelerating expansion of the Universe -- and potentially render the mysterious dark energy obsolete.

The post New Solution to Cosmic Acceleration Challenges Dark Energy Paradigm appeared first on Sci.News: Breaking Science News.

Using ESO’s Very Large Telescope (VLT), astronomers have captured a breathtaking shock wave around the white dwarf star 1RXS J052832.5+283824 (RXJ0528+2838 for short) -- a phenomenon that doesn’t fit existing models and could reshape our understanding of stellar evolution.

The post Unexpected Shock Wave Detected around Nearby White Dwarf appeared first on Sci.News: Breaking Science News.

A long-standing mystery in vertebrate evolution -- why most major fish lineages appear suddenly in the fossil record tens of millions of years after their presumed origins -- is tied to the Late Ordovician mass extinction.

The post Study: Late Ordovician Mass Extinction Cleared Way for First Fishes appeared first on Sci.News: Breaking Science News.

Famed dino likely spent much of its life competing for food against smaller predators

Terahertz instrument at Dome A, world’s driest spot, traces the faint glow of gases beyond other telescopes’ reach

Analysis of 41 million papers finds that although AI expands individual impact, it narrows collective scientific exploration

Small seed “parachutes” may be causing inbreeding

Mission to Canada’s Queen Elizabeth Islands reveals degradation of a sea ice haven

Painting roofs white and adding screens to doors and windows is a low-cost way to increase comfort and curb malaria risk

Homo habilis, 2 million years old, was known mainly from teeth and jaw bones

Observation challenges understanding of how dead stars interact with their environments

Scientists welcome GSK announcement that two trials succeeded—even though data are still lacking

Far from the icy Arctic, ancient South Americans hunted whales using whalebone tools

A piece of woolly rhinoceros flesh hidden inside a wolf that died 14,400 years ago has yielded genetic information that improves our understanding of why one of the most iconic megafauna species of the last glacial period went extinct

Some of the world’s biggest megacities are located in river deltas threatened by subsidence due to excessive groundwater extraction and urban expansion, compounding the threat they face from sea-level rise

A decades-long push to identify clear biomarkers for anxiety and depression is at last achieving results

A Chinese application to the International Telecommunications Union suggests plans for the largest satellite mega constellation ever built – but something else might be going on here

An analysis of growth rings in the leg bones of 17 Tyrannosaurus rex individuals reveals that the dinosaurs matured much more slowly than previously thought, and adds to the evidence that they weren't all one species

Easing stress is one of the healthiest pursuits you can embark on this January. Here are some evidence-backed ways to ground yourself in 2026

Construction generates between 10 and 20 per cent of the world's greenhouse gas emissions, but cities can slash their climate impact by designing buildings in a more efficient way

A report warns that we may have seriously underestimated the rate of warming, which could damage economic growth

A few extra minutes of sleep per day or an extra half-serving of vegetables with dinner can add a year to our lives, according to an analysis of data from 60,000 people

Clues from studies of ancient plants and animals have helped archaeologists pin down where the last Neanderthals found refuge, says columnist Michael Marshall

Graphene has long been hailed as a "wonder material." It is incredibly strong, highly conductive and almost impossibly thin—just one atom thick. These properties make it a promising candidate for next-generation technologies such as flexible electronics, wearable devices and printed sensors. Yet despite years of research, turning graphene into practical, printable inks has remained a major challenge.

Physicist Davide Bossini from the University of Konstanz has recently demonstrated how to change the frequency of the collective magnetic oscillations of a material by up to 40%—using commercially available devices at room temperature.

A Monash University study has found significant disparities in employment and work participation among LGBTQ+ Australians, highlighting ongoing structural inequalities in the labor market.

A by-product of rice bran oil production has long been recognized as a source of beneficial lipids for skin health and nutrition. Now, researchers have uncovered an entirely new class of skin-active molecules hidden within this agricultural residue.

Tired of hauling your boat out of the water to clean its hull? Graphene can replace the toxic chemicals usually used to do this job.

For quantum computers to outperform their classical counterparts, they need more quantum bits, or qubits. State-of-the-art quantum computers have around 1,000 qubits. Columbia physicists Sebastian Will and Nanfang Yu have their sights set much higher.

Visitors may believe they freely choose what to see in a museum, but new research shows that design decisions, often invisible to the visitor, play a decisive role in shaping attention, movement and discovery.

Piezoelectric nanoparticles deployed inside immune cells and stimulated remotely by ultrasound can trigger the body's disease-fighting response, according to an interdisciplinary team of Boston College researchers.

In today's hyperconnected world, social media has become a critical channel for businesses to understand consumers. While social listening tools are widely used, they often fall short, providing only a superficial understanding of consumer sentiment. Existing methods struggle to capture the full spectrum of emotions beyond basic sentiment (positive, negative, neutral), hindering companies' ability to truly understand their customers and make informed decisions.

Texas A&M University told philosophy professor Martin Peterson in early January 2026 that he could not teach some of Greek philosopher Plato's writings that touch on "race and gender ideology."

A 67-million-year-old claw fossil reveals a new dinosaur species that may have used its hand spikes to snatch and pierce eggs.

Signals transmitted via leaves can warn neighboring plants of stressful events, making the group collectively more resilient than plants in isolation.

Nicola Dell, a computer scientist studying the role of technology in intimate partner violence, cofounded the Center to End Technology Abuse.

An analysis of global climate data shows sustained warming even as El Niño faded.

Flower designs on 8,000-year-old Mesopotamian pots reveal a “mathematical knowledge” perhaps developed to share land and crops, archaeologists say.

A study on rabbits dosed with viper venom suggests that botulinum toxin may alleviate some effects of snakebite, possibly by dampening inflammation.

The density of fine hairs on bumblebees’ tongues determines how much nectar they can collect — and workers put queen bees to shame.

Black-bulb yam’s mimicry tricks birds into spreading its berrylike clones. The plant's novel strategy helps it spread without seeds or sexual reproduction.

In humans, teens do the most dangerous things. In chimpanzees, that honor goes to toddlers. The difference may lie in caregiver supervision.

The elm zigzag sawfly has spread to 15 states in five years. Now it's attacking the tree that cities planted to replace Dutch elm disease victims.

The levying of a 13% tax on condoms sold in China from Jan 1 is the country's latest policy aimed at reversing its falling total fertility rate (TFR; the average number of children a woman might expect to have in her lifetime); additionally, couples can claim cash payments of 3600 yuan (US$500) a year for each child younger than 3 years, as part of a scheme announced in July, 2025. China is one of more than half of all countries where the TFR is below 2·1 births per woman, the level required to keep the population stable.

Neisseria gonorrhoeae inexorably develops resistance to antimicrobials used for treatment. The discovery of novel antimicrobials to treat gonorrhoea is a global priority and antimicrobial-resistant N gonorrhoeae has been identified as an urgent public health threat.1,2 Ceftriaxone remains the primary recommended regimen for gonorrhoea treatment globally. However, reports from China, Cambodia, Viet Nam, and the UK, among other countries, signal a rising threat to the preeminent place of ceftriaxone within the gonococcal treatment armamentarium due to decreased susceptibility to ceftriaxone and periodic ceftriaxone treatment failures, highlighting the importance of enhanced global antimicrobial surveillance to monitor resistance trends.

Despite progress since 2020, including the approval of immunotherapy as third-line treatment, relapsed or refractory follicular lymphoma remains a clinical challenge, particularly among patients with early progression or resistance to anti-CD20-based regimens. Although the combination of lenalidomide and rituximab is a well established, chemotherapy-free option endorsed by international guidelines, outcomes remain suboptimal in high-risk populations, underscoring the need for novel therapeutic strategies.

Follicular lymphoma remains an incurable malignancy characterised by successive relapses. Despite favourable initial responses to front-line therapy, most patients eventually relapse, and lymphoma or treatment-related complications remain the leading cause of death.1 Accumulating evidence shows that the duration of response shortens with each subsequent line of therapy, resulting in progressively reduced progression-free survival and overall survival after each line of treatment.2,3

The study by Steven J Frank and colleagues1 in The Lancet is the first randomised, phase 3 trial comparing intensity-modulated proton therapy (IMPT) with intensity-modulated radiotherapy (IMRT) in patients with oropharyngeal cancer. Support for the role of proton radiotherapy for head and neck cancer has previously come from dosimetric studies,2 as well as retrospective and case–control clinical reports.3–5 A study with early experience from the MD Anderson Cancer Center compared 50 patients treated with IMPT with 100 patients treated with IMRT, finding a significant reduction in acute gastrostomy tube use and severe weight loss with IMPT, but no difference in tumour control.

The history of human health and migration, the human story, is deeply intertwined with the natural environment. As described by Anthony McMichael,1 pioneering scholar of health and environmental change, the climate is not merely a backdrop to human life, it is embedded in who we are and how we live. Modern human civilisation has been facilitated by the remarkably stable climatic conditions of the Holocene: the past 11 000 years during which century-to-century global average temperatures varied by no more than 1°C.

Global Health Watch 7 (GHW7) is an important intervention in the theory and practice of global health, especially at a time of upheaval and uncertainty. (I am writing these words as I listen to the news that US forces have bombed Venezuela's capital, Caracas, and captured, arrested, and indicted the country's dictator-President Nicolás Maduro and his wife, Cilia Flores: the prospects for a rules-based world order have just swerved sharply towards danger.) The co-editors of GHW7, Ron Labonté and Chiara Bodini, have succeeded in offering alternative narratives to challenge prevailing beliefs and assumptions in global health—a discipline that rarely challenges the political and economic foundations of its work.

Poland's approach to diagnostics, treatment, and prevention has been transformed, improving care for both refugees and Poles. Ed Holt reports.

Surging demand for AI has driven the frenzied construction of data centres, with concern over their health impacts. Faith McLellan reports.

“When I was really little”, says Rachel Clarke, looking back to her days at primary school, “we had to write a book called All About Me. Mine has a picture of me at a desk saying ‘When I grow up, I am going to be a writer of books.’” Clarke has more than fulfilled her childhood ambition and is the author of four books. The Story of a Heart, her account of a cardiac transplant from one child to another, won the UK's 2025 Women's Prize for Non-Fiction. Clarke divides her time equally between writing and work as a palliative care specialist in the UK.

Yellow fever vaccine was among the first successful human vaccines to be invented and has been in use for over 80 years. The vaccine is made by culture in eggs, a process with limited capacity that cannot be rapidly scaled up in response to outbreaks. The global stockpile of yellow fever vaccine for outbreak response is 6 million doses.1 In 2016, during yellow fever outbreaks in Angola and the Democratic Republic of the Congo, the global stockpile of yellow fever vaccine was almost exhausted twice.

Small and realistic increases in MVPA of 5 min/day might prevent up to 6% of all deaths in a high-risk approach and 10% of all deaths in population-based approach. Reducing sedentary time by 30 min/day might prevent a smaller, but still meaningful, proportion of deaths in the two risk scenarios.

The management of advanced non-small-cell lung cancer (NSCLC) with activating mutations in EGFR has evolved over the past 20 years. Whether used alone, or in combination with chemotherapy or the bispecific anti-EGFR MET antibody amivantamab, third-generation EGFR tyrosine kinase inhibitors (TKIs), such as osimertinib, are the backbone of treatment. Repeat tissue biopsies following progression on EGFR TKIs identify targetable genomic and histological changes driving TKI resistance in a subset of patients.

Compared with the standard yellow fever vaccine dose, a dose of 500 IU did not meet the non-inferiority criterion, suggesting that minimum dose requirements in adults are not generalisable to infants. Therefore, standard yellow fever doses should be used for infants in the routine WHO Expanded Programme on Immunization.

The savolitinib–osimertinib combination improved PFS versus chemotherapy in patients with EGFR mutation-positive, MET-amplified NSCLC that had progressed on EGFR TKI therapy, while maintaining a favourable tolerability profile. This regimen offers a potential oral treatment option for this biomarker-selected population.

Tetanus, although preventable by a highly effective vaccine, continues to cause 30 000–50 000 deaths annually. Global mortality has fallen substantially since the 1980s due to widespread vaccination efforts, yet adult disease persists, especially among those with weakened immune response, diabetes, and people who inject drugs. Diagnosis is still clinical, and management combines wound debridement, antibiotics, and antitoxin. However, key questions about prevention, diagnosis, and management remain unanswered.

In 2015, WHO defined vaccine hesitancy as a “delay in acceptance or refusal of vaccines despite availability of vaccination services”.1 More recently, it has been argued that the concept should be redefined as a “psychological state of indecisiveness that people may experience when making a decision regarding vaccination”,2 thereby distinguishing hesitancy from the final vaccination decision. Indeed, although hesitancy remains an internal state of indecision preceding the behavioural outcome related to vaccination, it is the actual choice a person makes about vaccination (ie, acceptance or refusal) that represents the behaviour itself.

The sixteenth Ebola virus disease outbreak declared on Sept 4, 2025, in Bulape Health Zone, DR Congo, underscores the persistent vulnerability of health-care providers during the onset of epidemics.1

Our findings suggest that most COVID-19 vaccine hesitancy was rooted in concrete concerns that can be addressed and successfully overcome with time and increasing availability of information. These findings should help future vaccination roll-outs to encourage vaccine acceptance.

The Advisory Committee on Immunization Practices (ACIP) has voted eight to three to withdraw the long-standing recommendation for universal hepatitis B vaccination at birth for infants born to mothers who test hepatitis B virus-negative, instead recommending shared clinical decision making and delaying the first dose to no earlier than 2 months for those not vaccinated at birth.1 This decision is a departure from evidence-grounded immunisation policy and should not be implemented without a transparent rationale and a credible plan to prevent predictable implementation failures.

Organizations across industries continue to explore how to fully incorporate artificial intelligence into their workflows. Ben Castleton, principal consultant for data quality at CDW, breaks down the technical components necessary for AI to operate in an enterprise to four essential parts: Click the banner below to read the new CDW Artificial Intelligence Research Report.

Agentic artificial intelligence is reshaping how some healthcare organizations coordinate care, streamline patient journeys and expand access to critical services. It’s not just a passive tool; it’s supporting information analysis and orchestrating complex workflows across clinical and administrative environments, including improving screening pathways and easing care transitions. “By stabilizing IT infrastructure, agentic AI helps lay the foundation for more advanced, front-end automation,” says Mutaz Shegewi, senior research director for worldwide healthcare provider AI, platforms and...

Strong identity and access management is an integral part of zero-trust security, but security teams may may be using too many tools to address this important pillar. Read on to discover how security tool sprawl came to be and how organizations can better address it to simplify and streamline their systems. Click the banner below to read the recent CDW Cybersecurity Research Report.

As technology has become a foundational element for healthcare organizations, cyber resilience has become an essential objective for their continued operation, IT experts said at a recent CDW Executive SummIT in Las Vegas. “There are three key principles for resilience: being able to predict, overcome and recover from an attack,” said Hector Cabrera, cybersecurity architect at Cisco Systems, who spoke during a panel at the event. “In business, that helps us meet our key performance indicators as well as keep employee trust and customer trust.” Members of the panel on which Cabrera spoke...

As healthcare organizations continue to adopt artificial intelligence to increase staff productivity and to improve clinical workflows, patient experiences and health outcomes, more strain will be put on data centers. To accommodate this trend as well as the rise in extreme weather events, healthcare organizations need a modern approach to cooling. Traditional data centers relied on air-based cooling. For AI, experts say that organizations will likely need to upgrade to a liquid cooling system. Here are five questions to ask about liquid cooling technologies: RELATED: Here are the four AI...

At this point, healthcare organizations are unfortunately more than familiar with ransomware — it’s not a matter of if but when. Providers are expected to stay vigilant and enhance their cyber resilience. But what happens when an attack isn’t a quick hit? What happens when a malicious actor or group has entered your network undetected, through stolen credentials or any type of backdoor access such as a zero-day vulnerability, and is just lying in wait? Then, after they’ve attacked once, what happens if they never lose that access and attack again? These are advanced persistent threats (APTs...

Technical debt is the accumulation of future costs that come with every IT product in your portfolio. For many IT managers, managing technical debt is a careful balancing act to ensure expenditures are predictable and problems are avoided. Security debt is a variation on technical debt — and a bigger problem in healthcare. Click the banner below to read the recent CDW Cybersecurity Research Report.

While more patient data is collected every day in the healthcare industry, patients’ access to that data is still lacking. To address this issue, the Centers for Medicare & Medicaid Services (CMS) wants to make patients’ medical data more accessible in real time, enabling patients to be better informed about their health and care options, according to its deputy administrator and chief of staff. Speaking at a NVIDIA GTC event in Washington, D.C., recently, Stephanie Carlton said the Trump administration is working with the healthcare industry to improve data accessibility rather than...

Mergers and acquisitions among hospitals and health systems recovered in Q3 compared with the first half of 2025, according to a new report from Kaufman Hall with 15 announced transactions. The company anticipates an uptick in M&A activity heading into Q4. “Now that the One Big Beautiful Bill has passed, hospitals and health systems have more policy clarity to inform their growth strategies,” said Anu Singh, managing director at Kaufman Hall, in the introduction to the report. “We expect that organizations will continue to seek resilience and growth by investing beyond the hospital and...

On November 1, Microsoft implemented its new pricing approach for online services purchased through its volume licensing programs. While the change won’t take place for organizations until their next agreement renewal unless they purchase new online services, it’s important for healthcare organizations to have a plan in place when that time comes. This change impacts services such as Microsoft 365 and Microsoft Intune; business analytics services like Power BI, Power Automate and Power Apps; security services such as Microsoft Defender; and device management services such as Active Directory...

Catch up quickly with our weekly round-up of key news stories for general practice.

Upheaval in ICBs and a failure to create jobs to bring newly-qualified GPs into the NHS workforce are major threats to the rollout of neighbourhoods, a government document warns.

Government plans to prioritise UK medical graduates for specialty training could guarantee almost all suitable UK applicants for general practice training are successful, NHS figures suggest.

Expecting neighbourhoods to deliver immediate savings to the NHS is unrealistic, GPs have warned.

MIMS Learning's Targeting Health Inequalities has been shortlisted in the Learning Awards 2026 - here's how you can vote to help it win.

PCNs or member practices could be served contract breach notices if their network fails to meet geographical requirements set by NHS England as neighbourhoods take shape, GPs fear.

UK medical graduates could be given greater priority for specialty training - including in general practice - in future as the government prepares to table legislation in parliament.

General practice in England has lost almost 700 full-time equivalent GP partners since the last general election - but numbers of younger partners in particular are in freefall, raising major questions over the profession's future.

General practice must be rebuilt over the coming decade around its core strengths including continuity, comprehensiveness and person-centred care to avoid being ‘hollowed out by private medicine’, a policy expert has warned.

A transcript of Talking General Practice’s recent interview with the new RCGP chair where she talked about how to restore joy and pride in general practice

Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.

This Viewpoint discusses the importance of understanding the evolution and current trajectory of state-level vaccine requirements for assessing the stability of the nation’s immunization infrastructure.

JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, spoke with JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, for JAMA+ AI Conversations.

Otho B. Ross Jr., M.D., Charlotte, N. C.

The Original Investigation titled “Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial,” published December 9, 2024, was corrected to clarify the noninferiority approach described in the Methods section and also to replace eFigure 3 with correct data in the first plot. This article was corrected online.

A new online calculator may help determine relative risk for long-term cardiovascular disease (CVD) for adults aged 30 to 59. The tool uses metrics including blood pressure, cholesterol levels, and body mass index to compute an individual’s 30-year CVD risk relative to others.

Results from a new international survey show concerning levels of burnout among primary care physicians (PCPs), especially in the US.

On the first World Cervical Cancer Elimination Day on November 17, the World Health Organization (WHO) shared major milestones in global efforts to protect women and girls from the preventable disease.

Chronic pain may increase the risk of high blood pressure in adults.

Psychiatry

Medical Education

This cross-sectional study investigates rates and characteristics of emoji use in clinical notes within electronic health records.

This cross-sectional study evaluates how directed acyclic graphs are constructed, reported, and applied for statistical adjustment across leading clinical journals.

This randomized clinical trial examines whether the benefits of a patient-focused self-management intervention promoting benzodiazepine cessation could be replicated when the intervention was converted from paper and pencil to electronic format.

This cohort study assesses health care costs associated with Lyme disease, stratified by localized and disseminated disease, among patients in the US.

This systematic review and meta-analysis examines the quality of life among parents of preterm infants and identifies modifiable factors associated with parental quality of life in the postpartum period.

This cohort study examines adverse events associated with stereotactic radiotherapy combined with concurrent biological cancer therapy in patients with metastatic or oligometastatic cancer.

This cohort study examines the characteristics of adult outpatients with community-acquired pneumonia who underwent diagnostic testing for blastomycosis, coccidioidomycosis, or histoplasmosis and received diagnoses for these diseases.

This cross-sectional study of US medical residents in high-burnout specialties examines the association of longer work hours with stress, burnout, and self-perceived competency.