Nature, Published online: 28 November 2025; doi:10.1038/s41586-025-09938-4

Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Nature, Published online: 28 November 2025; doi:10.1038/s41586-025-09952-6

Author Correction: Evidence for improved DNA repair in the long-lived bowhead whale

Nature, Published online: 28 November 2025; doi:10.1038/d41586-025-03797-9

Researchers have struggled to precisely edit mitochondrial DNA, but new techniques are bringing this ability within reach.

Nature, Published online: 28 November 2025; doi:10.1038/d41586-025-03877-w

Studying trapped antimatter could help to explain why our world is so full of matter.

Nature, Published online: 27 November 2025; doi:10.1038/s41586-025-09953-5

Author Correction: Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants

Nature, Published online: 27 November 2025; doi:10.1038/s41586-025-09947-3

Author Correction: Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver

Nature, Published online: 27 November 2025; doi:10.1038/s41586-025-09955-3

Author Correction: Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

Nature, Published online: 27 November 2025; doi:10.1038/d41586-025-03891-y

Despite advances, AI models continue to be geared towards the needs of English-speaking people in high-income countries.

Nature, Published online: 27 November 2025; doi:10.1038/d41586-025-03506-6

Controversy has erupted after 21% of manuscript reviews for an international AI conference were found to be generated by artificial intelligence.

Nature, Published online: 27 November 2025; doi:10.1038/d41586-025-03778-y

The European country has long been recognized as a model of efficiency and innovation — here’s how its research ecosystem is organized.

Researchers analyzed data from over six million people to see how close residents lived to cannabis retailers. Neighborhoods near these shops experienced higher cannabis-related emergency visits compared with those farther away. The effect was strongest where multiple stores were packed into small areas. These trends suggest that store density plays a meaningful role in community health.

Researchers found that repeated head impacts can disrupt a key system that helps the brain wash away waste. In professional fighters, this system initially seems to work harder after trauma, then declines over time. MRI scans revealed that these changes may show up years before symptoms do. The work could help identify at-risk athletes earlier in their careers.

A large-scale Brazilian study found dangerous levels of toxic metals in popular children’s toys, with barium and lead topping the list. Researchers used sophisticated lab methods to identify 21 hazardous elements and test how easily they could be released when toys are mouthed. Even though only small fractions leach out, the total concentrations were so high that safety concerns remain critical.

A major review across 73 countries finds that access to antiseizure medications is rising, but safe prescribing isn’t keeping pace. Valproate—linked to serious birth defects—remains widely used in many regions despite WHO warnings. Limited access to newer drugs means millions may still be at risk. Researchers urge global education and stronger safeguards.

Researchers have directly observed Floquet effects in graphene for the first time, settling a long-running scientific debate. Their ultrafast light-based technique demonstrates that graphene’s electronic properties can be tuned almost instantaneously. This paves the way for custom-engineered quantum materials and new approaches in electronics and sensing.

ETH Zurich scientists have found the holy grail of brewing: the long-sought formula behind stable beer foam. Their research explains why different beers rely on different physical mechanisms to keep bubbles intact and why some foams last far longer than others.

Scientists have identified new anti-aging compounds produced by a little-studied blood bacterium. These indole metabolites were able to reduce inflammation, oxidative stress, and collagen-damaging activity in skin cell cultures. Three of the compounds, including two never seen before, showed particularly strong effects. The findings hint at a surprising new source for future skin-rejuvenation therapies.

Researchers have finally assigned a strange 3.4-million-year-old foot to Australopithecus deyiremeda, confirming that Lucy’s species wasn’t alone in ancient Ethiopia. This hominin had an opposable big toe for climbing but still walked upright in a distinct style. Isotope tests show it ate different foods from A. afarensis, revealing clear ecological separation. These insights help explain how multiple early human species co-existed without wiping each other out.

Princeton researchers found that the brain excels at learning because it reuses modular “cognitive blocks” across many tasks. Monkeys switching between visual categorization challenges revealed that the prefrontal cortex assembles these blocks like Legos to create new behaviors. This flexibility explains why humans learn quickly while AI models often forget old skills. The insights may help build better AI and new clinical treatments for impaired cognitive adaptability.

Data from over 47,000 dogs reveal that CBD is most often used in older pets with chronic health issues. Long-term CBD use was linked to reduced aggression, though other anxious behaviors didn’t improve. The trend was strongest among dogs whose owners lived in cannabis-friendly states.

An international team of scientists led by University of Rome Tor Vergata researchers has sequenced the genomes of 87 ancient and modern cats.

The post Domestic Cats Were Introduced to Europe around 2,000 Years Ago, Probably from North Africa: Study appeared first on Sci.News: Breaking Science News.

In 2009, paleoanthropologists found eight bones from the foot of an ancient human ancestor in 3.4-million-year-old sediments at the paleontological site of Woranso-Mille in the Afar Rift in Ethiopia.

The post Two Australopithecus Species Co-Existed in Ethiopia 3.4 Million Years Ago appeared first on Sci.News: Breaking Science News.

The genome of the vampire squid (Vampyroteuthis sp.) is one of the largest animal genomes, exceeding 10 billion base pairs.

The post Scientists Sequence Genome of Vampire Squid appeared first on Sci.News: Breaking Science News.

To celebrate 25 years since the completion of the International Gemini Observatory, students in Chile voted for the Gemini South telescope to image the Butterfly Nebula, which is also known as NGC 6302, the Bug Nebula, or Caldwell 69.

The post Gemini South Telescope Focuses on Butterfly Nebula appeared first on Sci.News: Breaking Science News.

In new research, an international team of researchers used high-resolution 3D imaging techniques, including microCT scanning, to reconstruct brain shapes from more than three dozen species.

The post New Study Reveals How Pterosaurs Evolved Flight-Ready Brain appeared first on Sci.News: Breaking Science News.

Paleontologists have analyzed an exceptionally long sauropod trackway at the West Gold Hill Dinosaur Tracksite in Colorado, the United States. Their results show that the giant dinosaur which made it may have been limping.

The post 150-Million-Year-Old Footprints of Limping Sauropod Dinosaur Found in Colorado appeared first on Sci.News: Breaking Science News.

Although dogs (Canis lupus familiaris) and wolves (Canis lupus) can interbreed and produce fertile offspring, hybridization between the two is far more rare than domestic and wild populations of other species.

The post Almost Two-Thirds of Breed Dogs Have Wolf Ancestry, Study Shows appeared first on Sci.News: Breaking Science News.

Researchers have tested protenemata, brood cells and sporophytes of Physcomitrium patens under simulated space environments, identifying spores as the most resilient, and subsequently exposed them to the space environment outside the International Space Station.

The post Moss Can Survive Long-Term Exposure to Elements of Space, New Experiments Show appeared first on Sci.News: Breaking Science News.

Ruhr University Bochum researchers Gianmarco Maldarelli and Onur Güntürkün highlight three central areas in which birds show remarkable parallels to conscious experience in mammals: sensory consciousness, neurobiological foundations, and accounts of self-consciousness.

The post Birds May Possess Fundamental Forms of Conscious Perception: Study appeared first on Sci.News: Breaking Science News.

Wolves, the wild ancestor of dogs, are the only large carnivores that have undergone domestication by humans.

The post Ancient Humans Introduced Wolves to Remote Baltic Sea Island 5,000 Years Ago appeared first on Sci.News: Breaking Science News.

A daily pill can prevent the crippling disease, but its maker won’t bring it to market

Technology that uses a less known sensory system to substitute for olfaction could one day help anosmic people detect some odors

Specialized appendage responds to female sex hormones, allowing males to find sex organs in the dark

Government pledges to more than triple research spending by 2030

Identity of the toe bones and other fossils could shake up the human family tree

DNA recovered from people buried at the site reveals surprises

Unusually obstructive plumage compromises the vision of two types of pheasants—a first in birds

Bats could form a bridge between marine and terrestrial mammals, scientists say

Nation was first to legally protect frozen landscapes, a key source of water

Policy drops “paylines” based on peer-review scores and requires geography and other factors to guide approvals

From drowned worlds to virtual utopias via deep space, wild ideas abound in Emily H. Wilson's picks for her favourite sci-fi reads of the year

Quantum theory fails to explain how the reality we experience emerges from the world of particles. A new take on quantum cause and effect could bridge the gap

Scientists have long tried to uncover the perilous journey humans took to reach the ancient land mass that now makes up Australia. Now, a genetic study has edged us closer to understanding how and when they achieved this

Google is reportedly in talks to sell its tensor processing units – a type of computer chip specially designed for AI – to other tech companies, a move that could unsettle the dominant chip-maker Nvidia

Dental problems often arise or get worse during pregnancy, and a new study hints that rapid changes to the oral microbiome at this time could be at least partly to blame

Domestic cats originated in North Africa and spread to Europe in the past 2000 years, according to DNA evidence, while in China a different species of cat lived alongside people much earlier

Logging and mining are destroying swathes of the Congo rainforest, with the result that African forests went from being a carbon sink to a carbon source in 2010 to 2017

Inspired by natural polymers like DNA, chemists have devised a way to engineer plastic so it breaks down when it is no longer needed, rather than polluting the environment

New Scientist Book Club members share their thoughts on our November read, Grace Chan's Every Version of You

The New Scientist Book Club is currently reading Iain M. Banks's classic sci-fi novel The Player of Games. In this extract, we meet protagonist Gurgeh for the first time

Have you ever seen a dog focused on nuzzling their expensive treat under a blanket, behind a couch cushion, or into a freshly dug hole in the backyard? You might think they are behaving like a paranoid doomsday prepper, but dogs aren't stockpiling their food due to anxiety about impending disaster.

Marine litter is a serious environmental problem worldwide. Reducing it would require implementing a global monitoring system, agreeing on the use of common methods and protocols for data collection, and categorizing all components of marine debris. This involves a tremendous scientific, political, and social effort at the international level—one that cannot be carried out with the same intensity by all countries—given the magnitude of what is still unknown about the pollution of seas and oceans, particularly the deep ocean, where the vast majority of marine litter accumulates.

The first Bible to feature a map of the Holy Land was published 500 years ago in 1525. The map was initially printed the wrong way round—showing the Mediterranean to the East—but its inclusion set a precedent which continues to shape our understanding of state borders today, a new Cambridge study argues.

When three bright minds from different disciplines come together, something exceptional can happen. This is exactly what Prof. Patricia Hidalgo, Dr. Beatrix Santiago-Schübel, and Dr. Mercedes Alfonso-Prieto achieved at Forschungszentrum Jülich. In an interdisciplinary project, they investigated how cells recognize and remove defective calcium channels—work that could prove significant not only for basic science, but also for future therapies for neurodegenerative diseases.

Writing using computers is a vital life skill. We are constantly texting, posting, blogging and emailing.

According to an EHU study, lack of social support leads to increased loneliness of bisexual people. The work by Garikoitz Azkona of the Psychobiology group explored the relationship between sexual orientation and loneliness. It detected the highest level of loneliness among bisexual people, above that of homosexuals and heterosexuals.

A new study published in Science Advances overturns a long-standing paradigm in climate science that stronger Northern Hemisphere summer insolation produces stronger tropical rainfall. Instead, a precisely dated 129,000-year rainfall reconstruction from a Cuban cave shows that the Caribbean often did the opposite, drying during intervals of intensified summer insolation.

The mega genus Begonia (Begoniaceae) is widely distributed in tropical and subtropical areas. It is one of the largest plant genera in the world with over 2,100 species. In China, the number of Begonia species has increased to 304 (including subspecies, varieties and natural hybrid species) in recent years.

Researchers at the Leibniz Center for Tropical Marine Research (ZMT) and the University of Bremen have studied the nutritional value of five edible seaweed species, including some lesser-known algae, and examined their potential for sustainable nutrition. The study, published in the journal Discover Food, shows that the analyzed species are rich in polyunsaturated fatty acids and have strong antioxidant properties as well as high protein and mineral contents.

A strong geomagnetic storm in spring 2024 brought the northern lights unusually far south, as the auroral oval expanded well beyond its typical position. "I am surprised at how sparse the measurement network is, even though we know that the impacts of space weather can vary greatly from one area to another," says Doctoral Researcher Otto Kärhä from the University of Oulu, Finland.

Canada has had more than a year of continuous measles transmission. The United States has until January to limit cases before losing status.

As action from the U.N.’s huge COP30 international meeting falls short, smaller groups are banding together to find ways to fight climate change.

Foot bones and other fossils have been attributed to Australopithecus deyiremeda, a recently discovered species that may shake up the human family tree.

A microphone on NASA’s Perseverance rover recorded the sounds of electrical discharges generated by dusty gusts.

Like exercise, gratitude takes many forms. Finding the right practice, research shows, is up to the individual.

Ancient collagen preserved in the bones of extinct Australian mammals is revealing their evolutionary relationships, leading to some surprises.

Simulations show that subsurface oceans on small moons may hit boiling conditions, potentially creating features like Miranda’s distinctive ridges.

Colorful lichen living on dinosaur bones reflect infrared light that can be detected by drones, which might lead to finds in remote areas.

Takanori Takebe’s strange investigation into whether humans can use the gut for breathing has surprisingly sentimental origins: helping his dad.

The grisly infrared camera footage records a never-before-seen hunting tactic. It may have implications for bat conservation.

There was a strange sense of relief at the eighth replenishment conference for The Global Fund to Fight AIDS, Tuberculosis and Malaria, which took place on Nov 21, in South Africa. The USA is by far the Global Fund's largest donor and its pledge of US$4·6 billion, while much less than the $6 billion it gave in 2022, surprised many, given the Trump administration's scorched earth policy in global health. Still, the total of $11·34 billion pledged, far short of the $18 billion target, was disappointing, if not surprising.

Climate change is not only an environmental crisis but also a defining health emergency of our time. Its cascading effects, from rising temperatures, extreme weather events, air pollution, and disrupted ecosystems, to food and water insecurity, are undermining decades of progress in global health and development.1 Already, millions of people worldwide are experiencing worsening respiratory and cardiovascular disease, infectious disease outbreaks, and mental health stress linked to climate extremes.

Patients with symptomatic moderate-to-severe and severe mitral regurgitation who cannot undergo surgery or transcatheter edge-to-edge repair (TEER) have few treatment options. In The Lancet, Mayra E Guerrero and colleagues1 report 1-year outcomes of the ENCIRCLE pivotal study on a fully percutaneous, transfemoral, transseptal transcatheter mitral valve replacement (TMVR) system (SAPIEN M3; Edwards Lifesciences, Irvine, CA, USA), positioning this therapy as a potential third interventional option.

Thrombosis remains a major cause of morbidity and mortality, with one in four deaths being related to blood clots.1 As a result, anticoagulants have become one of the most prescribed drugs worldwide.1 Anticoagulants are used to reduce risk of hospital-associated thrombosis, an umbrella term used for venous thromboembolism occurring during hospital admission and for up to 90 days post discharge. Hospital-associated thrombosis is responsible for 55–60% of all venous thromboembolism,2 with an estimated global incidence of 10 million cases annually.

Type 1 diabetes is an autoimmune disease in which the insulin-producing β cells in the pancreatic islets of Langerhans are destroyed by islet-autoreactive T cells in individuals with genetic predisposition to this disease.1,2 Despite considerable development in technologies improving glycaemic control, insulin replacement treats the symptoms of type 1 diabetes but not its cause, and diabetic complications arise that increase mortality. Therapy to prevent or intervene in the disease process and preserve β-cell function is needed, but immunosuppressive therapies have not led to durable patient benefit so far, with clinical efficacy being restricted to subgroups of patients.

After months of effectively dismantling the architecture of US global health engagement by closing the US Agency for International Development, reducing its annual global health awards by an estimated 67%, discontinuing support for Gavi, the Vaccine Alliance, and withdrawing from WHO, the Trump administration has released its affirmative vision of what comes next.1–3

In 1995 at the Fourth World Conference on Women, the world came together to endorse the Beijing Declaration and Platform for Action1 on gender equality and women's empowerment. On Oct 13–14, 2025, the world gathered once again in Beijing, China, for The Global Leaders' Meeting on Women,2 jointly held by China and UN Women, with representatives from more than 110 countries in attendance.

When scientists gather, it is not uncommon for them to lament a decline in the public's trust of science. The examples are well described: anti-vaccination movements, climate scepticism, COVID-19 conspiracy theories. But are we talking ourselves into premature failure? In October, 2024, the Pew Research Center surveyed 9593 US adults “to understand how Americans view scientists and their role in making public policy”. The survey was carefully designed to represent the US adult population in terms of gender, race, ethnicity, education, and political affiliation.

With more big pledges expected in the coming months, the result of The Global Fund's eighth replenishment allayed the worst fears. Ann Danaiya Usher reports.

Following a large drop in international aid, and the harms that followed, Tanzania is taking steps to decrease its reliance on external funding for health. Syriacus Buguzi reports from Dar es Salaam.

Concerted, politicised assaults on scientific knowledge are intensifying. In the USA, the Trump administration is using the proposed Compact for Academic Excellence in Higher Education policy to condition federal funds on ideological conformity.1

The current sociopolitical climate has made science a contested terrain. Polemical rhetoric and attempts to subordinate science to ideology are not only compromising research integrity, but also eroding public trust.1 Gender is central to these contestations: efforts to erase, ignore, and deny identities or politicise gender scholarship undermine scientific accuracy and accountability. Sex and gender, which defy binaries, shape risk exposure, disease manifestation, health-care access, and outcomes.

Heart failure is a complex clinical syndrome affecting around 70 million individuals globally. It has a prevalence of 2% in Europe and North America and approximately 1% in Asia and South America. Accurate diagnosis relies on the presence of typical signs and symptoms, elevated natriuretic peptide concentrations, and evidence of cardiac structural or functional abnormalities using cardiac imaging techniques. Approximately half of all heart failure cases are attributed to reduced left ventricular systolic function—classified as heart failure with reduced ejection fraction (HFrEF).

For almost 80 years, the US Centers for Disease Control and Prevention (CDC) has been the nation's immune system, detecting threats early, coordinating rapid responses, and safeguarding population health. Its deep bench of epidemiologists, laboratory expertise, support for health departments, and evidence-based recommendations have fought threats to the public's health. During 2025 that immune system has been compromised, prompting our resignations, following the firing of the US Senate-confirmed CDC Director Susan Monarez on Aug 27, 2025.

Atopic dermatitis presents with heterogeneous clinical features and complex immune dysregulation. While primarily driven by a T helper 2 (Th2)-skewed response, other T cell subsets and pathways, including the OX40-pathway, contribute to disease pathogenesis.1,2 Rocatinlimab, a fully human monoclonal antibody targeting the OX40 receptor (OX40R) on activated T cells, inhibits pathogenic OX40R+ T cells, offering a novel approach to rebalance T cell populations and reduce inflammation.3 In this Comment we outline and review the results of two phase 3 trials (ROCKET-IGNITE [IGNITE] and ROCKET-HORIZON [HORIZON]), published in The Lancet by Emma Guttmann-Yaski and colleagues, evaluating rocatinlimab in adult patients with atopic dermatitis.

Globally, the prevalence of chronic kidney disease is estimated to be approximately 850 million cases, with approximately 4 million individuals needing kidney replacement therapy for kidney failure. By 2050, chronic kidney disease is projected to become the fifth leading underlying cause of death worldwide. Despite its numerous causes, chronic kidney disease can be screened for, diagnosed, and staged with simple laboratory tests. Individuals with chronic kidney disease are at increased risk of kidney failure and many other health implications.

Rocatinlimab treatment resulted in statistically significant and clinically meaningful improvements across clinical endpoints, including the coprimary endpoints of EASI-75 response and vIGA-AD score of 0 or 1, in comparison with placebo and had a clinically acceptable safety profile in adult patients with moderate-to-severe atopic dermatitis.

Violence against women and children are egregious human rights violations. Globally, intimate partner violence is the most common form of violence,1 with nearly one in three women having been subjected to “intimate partner violence or non-partner sexual violence”.2 “Psychological violence is the most common form of intimate partner violence”3 and can be considered worse than physical intimate partner violence. Six in ten children younger than age 5 years are regularly subject to psychological violence or physical punishment from parents and caregivers.

Climate change inflicts substantial economic damage on developing African nations, threatening progress towards the UN Sustainable Development Goals. There are synergies between actions needed to tackle climate change and other ongoing development priorities for Africa, including infectious disease control, facilitating clean energy access, reducing air pollution, tackling malnutrition and food insecurity, and providing universal health coverage. Action to protect human health against climate change needs to be integrated into all systems that are responsible for delivering essential services and implementing policies across all sectors that underpin the attainment of key development priorities for Africa.

In adults with obesity or overweight and type 2 diabetes, statistically superior reduction in bodyweight compared with placebo was demonstrated by once-daily orforglipron as an adjunct to lifestyle modification, with a safety profile similar to other GLP-1 receptor agonists.

For anyone looking to work at Sentara Health, a good starting point is its online job search engine. With the right qualifications, there’s a breadth of remote roles to consider. These open positions aren’t limited to just one department: for example a remote senior-level cloud cybersecurity engineer, an addiction and recovery treatment services care coordinator with a master’s degree in counseling or social work, or a payment policy expert. At any time, the Virginia-based health system with more than 30,000 employees advertises dozens of remote openings alongside its evolving slate of in-...

Patients at Nebraska Methodist Health System can now fill out medical history questionnaires and other pre-appointment forms online before arriving at a clinic. They can also upload copies of their insurance cards and sign consent forms electronically rather than stress over filling out paper forms on clipboards in a waiting room. “It’s all streamlined for patients,” says Dr. Gregory Hutteger, a family physician who also serves as the health system’s chief medical information officer. “It sets the visit off on the right footing and shows that we’re working to give them the best...

Imagine if healthcare technology wasn’t implemented without nurses’ input, but instead was created with them, for them — designed around their expertise, needs and real-world experience. That’s how Mayo Clinic Chief Nursing Officer Ryannon Frederick is leading change as the multistate healthcare provider implements new solutions, including ambient technology and a generative artificial intelligence tool, to help nurses with their demanding workflows. “There's no limit to what we can do as nurses,” says Frederick, who is also a registered nurse. “I believe that nurses are the future of...

Johns Hopkins Medicine receives about 3 million scheduling calls from patients each year. So, when new contact center technologies and processes helped the organization trim its call volume by just 3%, that resulted in a $1.4 million reduction in operating costs. “That 3% drop in volume is due to three things,” says Vivian Zhao, chief patient access officer for the organization. “One is an artificial intelligence solution that offloads nonscheduling calls for us. Another is our online scheduling tool. The third is our callback-assist feature. Those three things help decrease our volume and...

As patient rooms evolve to become more interconnected and frictionless, interactive displays or digital whiteboards have emerged as versatile hubs for information, entertainment and self-service, especially when integrated with electronic health records and other data sources. Providers are leveraging in-room screens to provide real-time updates to patients, to inform family members when a clinician last visited and to prepare patients for discharge. In the process, these smart displays are reducing manual tasks so that clinicians can focus on care. Reid Health, which serves eastern Indiana...

Healthcare’s mission — prioritizing patients’ well-being — is struggling under the pace of cyberattacks. The numbers clearly demonstrate this threat. This year, there have been roughly 130 health systems attacked in a 90-day period. Cyber incidents correlate with an increase in mortality rates, a 30% rise in medical errors during events and an average of 17 days of operational disruption. We’re also seeing backup systems become prime targets, with 74% of attacks compromising them, underscoring how claims of “immutability” ought to be...

Healthcare organizations know what’s at stake if they are faced with a successful ransomware attack: downtime, loss of data and loss of patient trust, in addition to potential impact on patient outcomes or even closure — and that’s after paying the ransom. Security leaders are aware of the threats and bad actors out there, but cryptocurrency payments are making it more difficult to trace the source of attacks. These factors are why healthcare organizations must take prevention and resilience seriously. At the 2025 CHIME Fall Forum in San Antonio, healthcare security experts discussed tips for...

It’s a common refrain in hospitals, health systems and other enterprises: As technology increases in popularity and usefulness, the sprawl that ensues makes management and governance more difficult. In that sense, artificial intelligence tools follow in the well-worn footsteps of laptops, smartphones, tablets and wearable devices. Last year, Google introduced Google Agentspace, now part of Gemini Enterprise. The platform represents Google’s efforts to create a unified and secure “front door” for its powerful AI technology, according to Miguel Aguilar, Google Cloud strategic alliance lead at...

Microsoft Copilot+ PCs — Windows devices equipped with neural processing units (NPUs) — are transforming how healthcare organizations manage diagnostics, documentation and administration. With artificial intelligence (AI) running directly on the device, clinicians can process medical images, generate clinical notes and analyze patient data in real time without relying on cloud computing. This local processing enables faster, more accurate decision-making while helping physicians spend less time on paperwork and more time with patients. Beyond productivity gains, the Copilot+ PC architecture...

As more healthcare organizations implement artificial intelligence tools into their workflows, interoperability and data quality become increasingly important. Breaking down silos and cleaning data have been a focus of many organizations for years, but the AI boom is creating excitement among staff beyond IT, and now may be the time to gain clinician buy-in on data governance initiatives. That’s some of what healthcare leaders discussed at the 2025 CHIME Fall Forum in San Antonio. They explained how AI is impacting interoperability, how organizations need to adjust their approach to...

Many GP premises in Scotland are ‘unsuitable and unsustainable’, the Scottish health secretary has admitted - as he told LMCs the government is ‘looking at every possible option’ to fund improvements.

General practice in Scotland is heading into a 'pivotal' three-year period for its future, backed by a major funding deal that provides an opportunity the profession must grasp, BMA Scotland's GP committee chair has said.

The GPonline team discusses the key news stories affecting general practice.

BMA leaders have urged the government to call a halt to 'relentless attacks' on the profession and work with GPs to achieve shared aims around improving care.

Health and social care secretary Wes Streeting has accused the chair of the BMA England GP committee of 'deeply unprofessional' behaviour and misleading the profession, in a letter he sent directly to GPs.

A year on from the publication of landmark NICE guidelines on asthma, GP and clinical lead for Asthma + Lung UK Dr Andy Whittamore writes for GPonline about why their implementation is crucial.

Catch up quickly with our weekly round-up of key news stories for general practice.

Changes to pension tax and rumoured changes to national insurance that could have heaped extra costs on GP partners did not materialise in the 2025 autumn budget - but measures set out by the chancellor will have a substantial impact on many GPs. GPonline looks at the changes and expert reaction.

Chancellor Rachel Reeves has confirmed plans to create 250 neighbourhood health centres by 2035 with help from private investment in an autumn budget that will drive up costs for GP practices with a 4.1% rise in the minimum wage.

GP leaders fear the government is preparing to impose contract changes for 2026/27 on the profession after officials outlined plans to 'consult' with the BMA England GP committee alongside 'wider primary care stakeholders'.

Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.

W. Walter Menninger, MD

A recent study in JAMA Psychiatry found that, following recreational cannabis legalization in the US, cannabis uptake increased among individuals with psychosis more than in the general population.

Individuals with excess body fat who have higher grip strength tend to have a lower risk of obesity-related organ dysfunction and early death, new research suggests.

Invasive lobular carcinoma is now increasing faster than other types of breast cancers among US women. A recent study published in Cancer found that new cases of lobular breast cancer, which originates in the milk-producing glands, are climbing at a rate of nearly 3% per year, compared with less than 1% for all other breast cancers combined. As of 2021, 14 cases per 100 000 women with invasive lobular carcinoma have been reported, which accounted for 10% of breast cancer cases.

Almost a third of health care workers in Europe report symptoms of depression and more than 10% had suicidal thoughts within the past 2 weeks, according to results from a World Health Organization (WHO) survey. Working long shifts was associated with poorer mental health.

Narcolepsy may not be associated with increased mortality risk, according to a new study published in JAMA Network Open. Current research on this topic has been mixed.

About 1 in 5 young adults reported using alcohol or cannabis to fall asleep, according to a study published in JAMA Pediatrics. Although cannabis and alcohol can help initiate sleep, regular use may increase tolerance, worsen sleep problems, and lead to substance use disorder, the authors wrote.

This Medical News article is an interview with the lead author of a new European Society of Cardiology clinical consensus statement on cardiovascular disease prevention and management in COVID-19.

In the Original Investigation titled “Modified Clavien-Dindo Classification for Adverse Events in Otolaryngology–Head and Neck Surgery,” published October 27, 2025, there was an error in Table 2. In Table 2, the column reflecting the mean (SD) Comprehensive Complication Index (CCI) score was labeled as SD but should have been labeled: CCI, mean (SD). This article has been corrected.

Pediatrics

Pediatrics

This cohort study of survivors of breast, prostate, or colorectal cancer examines risk factors associated with late-onset depression.

This cohort study examines changes in hospitalization rates for neonatal bacterial infections and their associated costs following the introduction of the 2017 early-onset neonatal bacterial infection management guidelines in France.

This cohort study investigates the association between antenatal corticosteroids and bronchopulmonary dysplasia in very preterm infants and whether respiratory distress syndrome and invasive mechanical ventilation mediate the outcomes.

This cohort study evaluates neurodevelopmental outcomes among infants exposed in utero to antiretroviral therapy consisting of integrase strand inhibitor–based regimens compared with protease inhibitor– or nonnucleoside reverse transcriptase inhibitor–based regimens.

This cross-sectional study evaluates patterns of emergency department (ED) utilization by US veterans for low-acuity conditions during and after the expansion of virtual care within the Veterans Affairs Health System.

This cohort study investigates the associations of fetal exposure to hypertensive disorders of pregnancy with child developmental patterns up to age 4 years.

This cross-sectional study reports on how often patients in an integrated care setting use electronic visits for common outpatient conditions and if the rates of resolution differ from telephone, video, or office visits.