[Comment] Cardiovascular benefit of blood-pressure lowering in chronic kidney disease

Chronic kidney disease (CKD) has long remained at the margins of the evidence base for the cardiovascular benefits of blood-pressure lowering. The absolute risk of cardiovascular events in people with CKD is among the highest across major clinical populations.1 However, research into the cardiovascular benefits of blood-pressure lowering in this population has, for decades, relied largely on extrapolation, subgroup analyses, and secondary meta-analyses,2,3 rather than trials spanning multiple CKD stages with cardiovascular outcomes as primary endpoints.