[Comment] rVSVΔG-ZEBOV-GP vaccine-induced seroreactivity to Bundibugyo virus: a cross-protection dilemma

The virus family Filoviridae includes several species known to cause severe and often fatal disease in humans. Within the genus Orthoebolvirus, the majority of clinical disease cases and associated deaths have been caused by Orthoebolavirus zairense (Ebola virus; EBOV), which was responsible for a massive epidemic in west Africa from 2013 to 2016, resulting in at least 28 000 clinical cases of disease and 11 325 deaths.1 In addition to EBOV, Orthoebolavirus sudanense (Sudan virus), and Orthoebolavirus bundibugyoense (Bundibugyo virus; BDBV) have both caused substantial outbreaks, the latter of which has recently re-emerged in the Democratic Republic of the Congo, and as of Aug 27, 2026, has caused 5815 confirmed cases and 2788 deaths.