[Comment] Liver disease: screening for the elusive adversary

It is almost 60 years since the original Wilson and Jungner1 criteria for evaluating population screening programmes were published, with the tenets presented having stood the test of time. Liver disease is a curious case in which to apply these principles. Supporting the rationale for screening is the long-asymptomatic phase of disease and the very poor outcomes for late presentations. However, there is no consensus about who has a clinically relevant disease and who gets treatment, and the most accurate non-invasive testing approach undermines these justifications.